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Several hundred G6PD genetic variants exist, but most clinically significant hemolytic anemia is associated with only two variants, designated G6PD and G6PD Mediterranean

Its proposed mechanisms include modulation of ACTH release, antioxidant activity, and opioid system interaction, but most human evidence is weak or dated

Synthesis of nitric oxide from l-arginine by neutrophils

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It is noteworthy that the disulfide linkage between homocysteine and the cysteine-rich domain of annexin II is responsible for the homocysteine-specific inhibition of t-PA binding to annexin at the cell surface (Hajjar et al, 1998)