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"The interaction between the cytosolic pyridine nucleotide redox potential and gluconeogenesis from lactate/pyruvate in isolated rat hepatocytes

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5 Conclusion and future perspectives Changes in metabolism play a crucial role in shaping the extent and nature of T cell differentiation and function, with a metabolically hostile TME often leading to infiltrated T cell dysfunction, which seems to be the most prominent roadblock in CAR-T cell therapy against solid tumors