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There were 270 encounters during the study period where patients received treatment from one of the order sets and 177 who met all criteria for final analysis

Nat Rev Neurosci 14(6):383400

Trastuzumab-induced cardiomyopathy via ferroptosis-mediated mitochondrial dysfunction

Based on the cholinergic hypothesis of memory formation it was originally proposed that drugs designed to inhibit central and peripheral acetylcholine esterase (AChE), and serve as a muscarinic M2 autoreceptor antagonist, would result in facilitated release of ACh

Lipid peroxidation by-products, including primary lipid hydroperoxides (LOOH), malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), continuously accumulate during ferroptosis in cancer cells and facilitate cell membrane rupture and ferroptosis occurrence (Tang et al., 2021)