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Its widespread use reflects the importance of maintaining consistency and precision throughout the handling process

However, in genetically predisposed individuals, a subset of autoreactive T cells can evade these mechanisms, become activated, proliferate, and differentiate, initiating an autoimmune cascade (Fig

The main exception to this rule is the GLP-1 class (like semaglutide, tirzepatide, or retatrutide), which may be used for longer under proper supervision since the studies and pharmacology support extended duration

Moreover, medical boards underscore the need for strict protocols, yet enforcement remains inconsistent