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Since the low-molecular-weight antioxidants glutathione (GSH) and thioredoxin (Trx-Red or Trx-SH) are cofactors of various enzymes, we may include them in the first line of antioxidant defense (Ighodaro and Akinloye 2018)

Overexpression of the histone dimethyltransferase G9a in nucleus accumbens shell increases cocaine self-administration, stress-induced reinstatement, and anxiety