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This comprehensive TME reprogramming creates strategic therapeutic synergies, particularly with immune checkpoint inhibitors

Melanoma-associated antigen A6 (MAGEA6) with oncogenic activity is highly expressed in triple-negative breast cancer (TNBC) cell lines and tumor tissues and is involved in the acquisition of drug resistance

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Finally, the present analysis provides additional evidence in favor of recommending the use of AOX therapy in male infertility (Table 5)

Thus, knock-out of metabolic genes (mainly the 35 genes predicted to be essential by the consensus models) was performed utilising the IN-HOUSE (Fig