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The antigens against which these autoantibodies are directed include a number of CNS antigens, such as myelin basic protein and neuron-axon filament protein, but they also include a whole host of other proteins, such as nerve growth factor, serotonin receptor, alpha-2-adrenergic receptor, tubulin, heat shock protein 90, and chondroitin sulfate (Connolly et al., 1999

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It is supposed to enter the TCA cycle as acetyl coenzyme A (AcCoA) after the oxidative decarboxylation by pyruvate dehydrogenase in normal metabolic status [60], but it turns out to be priorly transferred into LA in cancer cells and then shuttled to adjacent cells or stroma [61]

Suppression of IL-10/STAT3 or TGF-/SMAD-dependent antioxidant circuits enables the restoration of lipid peroxidation susceptibility in adjacent tumor cells (107)