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Notably, C57BL/6 male mice that received sulforaphane in conjunction with depression-inducing lipopolysaccharide, exhibited lower depressive behaviours on the tail-suspension test and forced swimming test compared to those that did not receive sulforaphane (Zhang et al., 2017)

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Cycling Considerations Most protocols recommend cycling off after 12 to 16 weeks to prevent potential receptor desensitization and maintain hormonal sensitivity