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After FDA approval of enasidenib, a first-in-class drug targeting cancer metabolism via inhibition of IDH2 activity, more studies were conducted with R-2-HG positioned as an oncometabolite

This analogy is important both for conceptualizing the uric acid crystals in the joint and for understanding the various types of gout treatment (see below), some of which attack the inflammation (pour water on the flaming matches) and some of which remove the uric acid crystals (take away the matches)

Check out this clip from our conversation, and watch the full interview to hear more about research from clinical trials: To view or add a comment, sign in Japanese Quality: What Makes Our Supplements Different In Japan, quality isnt an afterthought its a philosophy

PMID: 188 MareaiS

Emerging concepts in oligodendrocyte and myelin formation, inputs from the zebrafish model