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In the present study, we demonstrated for the first time that hepatoma-derived growth factor (HDGF) enhances angiogenesis in non-small cell lung cancer (NSCLC) cells expressing vascular endothelial growth factor (VEGF) and that fibroblast growth factor-2 (FGF-2) is a VEGF-independent angiogenic factor in VEGF-downregulated NSCLC cells (Fig

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