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In vivo , apigenin reduces the secretion of pro-inflammatory factors (IL-1, IL-6, and TNF-), reduces the expression of the DCs costimulatory molecules CXCR4 and MHCII, and reduces the number of Langerhans cells

Sebaratnam said one of the main concerns about melanotan was whether it could stimulate pigment cells to become a melanoma - one of the deadliest forms of skin cancer