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CISD2 plays a role in age-related diseases and cancer

B7 variants which act through CD28 with improved activity (and with decreased activity through CTLA-4) are expected to have improved capacity to induce activation of T cells

They usually occur in the initial phase of starting the treatment or during dose escalation, but improve over time

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Two major pathways of LTB4 inactivation are known, and responsible enzymes have been identified