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This study employed Saccharomyces cerevisiae as an eukaryote model to evaluate the possible effects of melatonin supplementation on endogenous cellular defense systems by measuring its effects on various cellular targets

Experimental studies have shown that methylation activity is lower in hypothyroidism, and higher in hyperthyroidism

This interaction is mediated through the pathways of the nervous, immune, endocrine, and metabolic systems, playing a pivotal role in modulating states of anxiety, depression, and cognitive abilities, also impacts the initiation and advancement of neurodegenerative disorders, including Alzheimer's (107) and Parkinson's diseases (108), along with other pathological states (Figure 3)

Localized heating alters ion permeability coefficients, as described by the Goldman-Hodgkin-Katz (GHK) equation (Equation 1), influencing membrane potential (Vm) and neuronal excitability

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