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Problems with B12 transporters or with vitamin-associated binding proteins

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Testing for 6-TG can identify patients who might benefit from allopurinol, a xanthine oxidase inhibitor that diverts the metabolism toward 6-TG

acting through intracellular signaling molecules called second messengers) that activate signaling pathways inside cells, whose responses are slower, and may be either excitatory (increased odds that message will be spread through the neural circuit) or inhibitory (decreased odds that message will be spread through the neural circuit), depending on which G-proteins they are coupled to, and, consequently, which signaling pathways they activate

Bone marrow-derived mesenchymal stem cells are precursors for stromal fibroblasts in tumors: Impleciations for cancer therapy