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The association of increased ROS production with enhanced detoxification and antioxidant activity of hepatic steatosis, but not with NASH, indicates that in NASH, the ROS overproduction mechanism may be inadequate [44]

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10.1016/j.jnutbio.2022.109061 48

Experimentally, peripheral administration of LPS in animals induces microglial activation and can exacerbate amyloid pathology and neurodegeneration [62]