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FIGURE 1 3 Core mechanistic roles of nAChRs in nicotine addiction As pivotal members of the ligand-gated cation channel superfamily, nicotinic acetylcholine receptors (nAChRs) serve as the cornerstone of nicotine addiction neurobiology, with the complexity of their molecular architecture and functional modulation forming its fundamental basis ( 2 10 ) and 3 subunits ( 2 4 ) have been identified

(2017) review systematically elaborated on the regulatory mechanisms of the microbiome on stress responses and the HPA axis

We break down further details of these flexibility and convenience options in the following section

Catalase (CAT) , a heme enzyme that catalyzes the decomposition of H 2 O 2 to water + molecular O 2 , provides a vital cellular antioxidant defense 570

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