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doi: 10.3389/fphar.2023.1145407 Received 16 January 2023 Accepted 27 March 2023 Published 04 April 2023 Volume 14 - 2023 Edited by Zhijie Xu, Central South University, China Reviewed by Xu-Sheng Liu, Hubei University of Medicine, China Fanhua Kang, Xiangya Changde Hospital, China Updates Copyright 2023 Zheng, Wang, Zhang, Chen, Liang, Liu, Qiu, Chen, Huang, Lu and Dai

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Another problem is that many studies investigating flavonoid effects use either whole plant extracts or diets containing flavonoids without isolating specific flavonoids

Moreover, simply release of iron from MOF-L was insufficient to induce cell death