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Cancers (Basel) 11(5):678 Ortmayr K, Schwaiger M, Hann S, Koellensperger G (2015) An integrated metabolomics workflow for the quantification of sulfur pathway intermediates employing thiol protection with N-ethyl maleimide and hydrophilic interaction liquid chromatography tandem mass spectrometry

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As shown in Figure 3, the choice of separation methodfrom traditional ultracentrifugation (A) to emerging aqueous two-phase separation (J)requires balancing yield, purity, and operational complexity