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Specifically, tocilizumab is administered at a dose of 8 mg/kg via intravenous infusion, with a maximum dose of 800 mg, given 12 times, not exceeding three doses within a 24-hour period, up to a maximum of four doses

Disadvantages: Because drug release depends on antibody degradation, non-cleavable linkers generally exhibit slower onset of action, which may limit efficacy in situations requiring rapid, high-intensity drug effects

Protective effect of the synthetic protease inhibitor E3123