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In clinical trials, consumption of broccoli sprout beverages increased urinary excretion of airborne toxin conjugates and supported glutathione S-transferase activity

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The regulatory effect of metformin on the microbiota extends beyond GSH to include microbial metabolites such as short-chain fatty acids (SCFAs), which have been shown to inhibit tumor proliferation and protect against intestinal injury [34,35,36]

Together, these results indicate that ER is recruited to the ERE-containing promoters in SLC7A11 and SLC3A2 , thereby enhancing SLC7A11 and SLC3A2 expression in response to estrogen stimulation in ER+ breast cancer cells