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There is also an isoform of GPx in intestinal epithelial cells, which is thought to have a role in detoxification of dietary hydroperoxides

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Studies have shown that ERK1/2 is a conserved serine/threonine kinase, and its direct or indirect interactions with the PI3K/Akt, -catenin, and Janus Kinase/Signal Transducer and Activator of Transcription (Jak/Stat) signaling pathways collectively mediate cell growth, regeneration, and proliferation

Additionally, it may serve a regulatory function in immune cells during acute liver injury and allergic asthma (Wang H

To address the issue, western blotting analysis was further performed to confirm that there were obvious decreased level of 4-HNE in LA-treated mice, compared with FA-injected ones, but no significant difference between the high- and low-dose groups was observed, as shown in Figure 5