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By flow cytometry and immunofluorescence analyses, we found that Abcc4 deficiency markedly enhanced LDL uptake (Fig

Kharaziha P, Hellstrm PM, Noorinayer B, Farzaneh F, Aghajani K, Jafari F, et al

Galpha(12) overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation

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That approval validated the core mechanism: stabilizing cardiolipin improves mitochondrial function in measurable, clinically significant ways