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Parkinson's Progression Marker Initiative* (2018) Longitudinal Change of Clinical and Biological Measures in Early Parkinson's Disease: Parkinson's Progression Markers Initiative Cohort

Other common symptoms include: Post-exertional malaise: Feeling worse after physical activity, often the next day Unrefreshing sleep: Waking up feeling unrefreshed, despite getting enough sleep Cognitive difficulties: Trouble concentrating and multi-tasking Orthostatic intolerance: Feeling lightheaded or experiencing a rapid heartbeat when standing up CFS/ME often involves cycles of flare-ups and remissions, with good days and bad days

3d) closely matches that of the theoretical isotope distribution of unlabeled TS (Fig