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For example, curcumin inhibits the methylation of lysine 4/9/27 on histone H3 in leukemia cells by inhibiting histone lysine methyltransferase (HKMT) and enhancing the activity of histone lysine demethylase (HKDMT) with consequent changes in gene expression that could contribute to its antitumor effect

In one embodiment, the polypeptide sequence of an Fc monomer is substantially similar to an Fc polypeptide sequence of: an Igd Fc region, an lgG 2 Fc region, an lgG 3 Fc region, an lgG 4 Fc region, an IgM Fc region, an IgA Fc region, an IgD Fc region and an IgE Fc region