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3b) [65,66,67]

Such temporal separation matters for target-tissue exposure, since early absorbed conjugates will mainly affect circulating tissues, while colonic-derived metabolites may exert both local gut effects and delayed systemic effects (Zhang et al., 2024a, b)

The cell membrane interaction is also important in determining the benefits and limits of liposomes [30]

Selenium is an essential mineral that may play a role in male and female reproductive systems

250,251,252 UA induced inflammation and relative mechanism Uric acid signaling triggers the activation of several transcription factors, such as NF-B or AP-1, through the activation of MAPK p38 and ERK pathways, resulting in the production of reactive oxygen species (ROS) under the conditions of hyperuricemia