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doi: 10.1016/j.ncl.2024.05.011 225 ZhangLHuRLiMLiFMengHZhuGet al

Regulation of uric acid metabolism and excretion

Bottom left: VX exerts toxicity through irreversible inhibition of acetylcholinesterase (AChE), causing accumulation of acetylcholine (ACh) at synapses and resulting in cholinergic overstimulation

Free Radical Biology and Medicine 69, 219228 (2014)

These mechanisms involve the gut flora, dysregulation of calcium signaling, mitochondrial dysfunction and oxidative stress, and pathological alterations in Tau proteins (Fesharaki-Zadeh and Datta, 2024)