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L2-Cmu proved feasible and well tolerated in older animals, and consistent with genetic models of IGF-1R heterozygosity 6,7,8 , improves female healthspan and lifespan

Beyond direct killing, LL-37 modulates host immunity: in murine sepsis models, it induced neutrophils to release microvesicles rich in antimicrobial proteins, lowering bacterial burden and improving survival [3]