Weakened immune system : Long-term use weakens the immune system and makes users more prone to infections
However, in the general mass, there are light yellow, translucent fractions, which looks more like reconstituted tobacco than bits of tobacco leaf

In this case, explained Matthew Farrelly, director of the Office of Science at the FDA's Center for Tobacco Products, "the strength of evidence of benefits to adult smokers from completely switching to a less harmful product was sufficient to outweigh the risks to youth." The FDA is applying a standard established by the Family Smoking Prevention and Tobacco Control Act of 2009, which says the agency should approve new nicotine products when they are "appropriate for the protection of the public health." The agency is supposed to take into account "the risks and benefits to the population as a whole, including users and nonusers." That, in turn, entails considering "the increased or decreased likelihood that existing users of tobacco products will stop using such products" as well as "the increased or decreased likelihood that those who do not use tobacco products will start using such products." In the ENDS context, as Farrelly's comment reflects, that evaluation comes down to weighing the benefit of a given product in helping adult smokers quit against the risk that it will appeal to teenagers

Theyre available at gas stations and convenience stores under names like Zyn, O
They produce counterfeit cigarettes with the look and feel of legitimate brands and sell them with counterfeit tax stamps