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Challenges in therapeutic translation Targeting specificity & off-target toxicity A major challenge is achieving cardiomyocyte-specific ferroptosis modulation without harming other cells

Moreover, STZ triggers apoptosis and cytotoxicity by elevating reactive oxygen species (ROS) and nitric oxide synthase production

To compare and analyze the impact of our suggested modifications, we ran a simulation using the most recent claims data from the December 2022 update of the FY 2022 MedPAR file

The convergence of ferroptosis and syn pathology underlines the multifaceted role of dysregulated iron metabolism in exacerbating neurodegeneration in PD