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Research question formulation The research question (RQ) of this study was formulated using the PICO (Population, Intervention, Comparison, Outcomes) framework

Genetically, ASD can be linked to identifiable genetic syndromes, such as Fragile X, Tuberous Sclerosis, Neurofibromatosis I, ADNP syndrome, and copy number variations (Lubbers et al., 2024

Furthermore, the presence of large mtDNA deletions in neuronal tissue has been linked to HIV sensory neuropathy ( The correlation between mtDNA copy number in PBMCs and cognitive performance suggests that systemic mitochondrial health reflects processes within the brain