hemochromatosis and glutathione Hemochromatosis: What It Is, Symptoms & Treatment Hemochromatosis: Understanding Iron Overload |

10.1126/science.aaw9872 23 BaiY.MengL.HanL.JiaY.ZhaoY.GaoH.et al

doi: 10.1016/j.ygeno.2022.110275 3 AdilM

Macro- ATG consists in the delivery of cytoplasmic cargo to the lysosome through the intermediary of a double membrane bound vesicle, the autophagosome, which fuses with the lysosome to form an autolysosome ( Accumulating data point to an essential role for ROS as mediators in the activation of ATG under several stimuli (starvation, pathogens, death receptors), even though the nature of this involvement remains still elusive

Since NA(D)PH, GSH, GPX4, CO-A, Fe2+, and H2S mediate the reduction of LPO and the production of ROS to regulate iron death, Cys is an important factor in the regulation of cellular iron death

However, the lack of human trials, quick degradability of liposomes and safety concerns of soy lecithin (a liposomal component) are barriers against its current use