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doi:10.1038/s41568-025-00881-0

This tension is called muscle tone. People with hypotonia have too little tension in their muscles and appear floppy. People with hypertonia have too much tension in their muscles and have problems with tight, rigid muscles and joints., called spasticityThis is rigidity of the muscles and increased reflexes

These conditions include megaloblastic anemia, neurological disorders, cognitive decline, cardiovascular issues, and complications during pregnancy (Figure 2), among others

In the long term, treated patients survived for longer because of this, than did untreated patients

Common formulations include 0.5 to 1.0 mg (500 to 1000 mcg) b12 per semaglutide dose