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However, with VIM DBS, effective tremor suppression can sometimes come with the price of worsening gait ataxia, a clinical observation that suggests that different neuronal coding mechanisms for tremor and ataxia lie within the same cerebello-thalamo-cortical loop [189]

Peptides are short chains of amino acids that act as messengers in the body, signaling cells to repair, regenerate, or regulate specific functions

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Trade-offs include less flexibility in dose adjustment and prolonged exposure if adverse effects develop