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In the Study of Tirzepatide in Participants with Heart Failure with Preserved Ejection Fraction with Obesity (SUMMIT) trial, tirzepatide significantly reduced the risk of death from cardiovascular causes or worsening heart failure events in patients with heart failure with preserved ejection fraction (ejection fraction 50% and above) and obesity (BMI 30 kg/m 2 ), compared with placebo (HR 0.62

Matsuoka, Y

in mM: 130 NaCl, 3.5 KCl, 10 glucose, 1.25 NaH 2 PO 4 , 2.0 CaCl 2 , 1.5 MgSO 4 , and 24 NaHCO3) or modified ACSF (ACSF without MgSO 4 ) bubbled with 95% O 2 /5% CO 2 for 15 min

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This combined approach makes BPC-157 of additional interest within broader research protocols