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Arsenic-induced mitochondrial instability leading to programmed cell death in the exposed individuals

Tang Y, Preuss F, Turek FW, Jakate S, Keshavarzian A

These results corroborate our previous findings ( Ferroptosis, a form of iron-dependent cell death characterized by oxidative lipid damage and impaired antioxidant capacity, has emerged as a key player in cisplatin nephrotoxicity ( , specifically its subunit xCT, impairs cystine uptake and GSH synthesis, weakening the antioxidant capacity of GPX4, the primary enzyme responsible for reducing lipid hydroperoxides