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Intramuscular injection of vitamin B 12 used to be the only known treatment for patients with vitamin B 12 deficiency after gastrectomy, however Hyoung-il 25 found that oral vitamin B 12 was one of the safe and effective alternative treatments

Tregs also highly express immune checkpoint molecules (e.g., CTLA-4, PD-1, GITR), which bind receptors on immune cells to inhibit effector activity [36]