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Clinical Status Human RCT | Observational | Animal | In vitro Primarily studied in preclinical and exploratory neurophysiological research contexts, with limited controlled human trials

Temple JL, Bernard C, Lipshultz SE, Czachor JD, Westphal JA, Mestre MA (2017) The safety of ingested caffeine: a comprehensive review

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Interestingly, Paraprevotella (AUC, 0.78), Pseudobutyrivibrio (AUC, 0.76), and Collinsella stercoris (AUC, 0.83) showed more superiority than the usual urine protein/creatinine ratio (AUC, 0.755) in discriminating CKD patients from healthy controls even at early disease stage