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These preliminary findings warrant further investigation in larger, placebo-controlled trials in order to more rigorously assess the safety, efficacy, and translational potential of this intervention for mitigating chronic cognitive sequelae in individuals with moderate to severe TBI

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However, they do not always have a specific definition, and, in some countries, supplements, herbal products, pre-and pro-biotics, and functional and fortified foods are not classified as nutraceuticals (Table 1)

Further investigations to explain the mechanism underlying glutaminolysis-induced metabolic reprogramming are needed