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MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

And those, it kind of brings me back to my early days of science, when I was at the Salk Institute for Biological Studies doing research on little nematode worms that we or someone else injected amyloid beta 42, the peptide, the 42-amino acid peptide that is involved in amyloid plaques found in the brain correlated with Alzheimer's disease and other brain disorders

In normal skin, keratinocytes are the main components of the epidermis and are fundamental to its protective barrier function 29

This response may be part of an emergency response with the sudden onslaught of oxidants from the CS exposure or it may be the depletion of GSH during the CS exposure combined with the increase in oxidants from CS that acts as a trigger to initiate this response

On full frame, you have a bit more room usually f/13 to f/16