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[PubMed] [Google Scholar] 108.Smyth J.F., Bowman A., Perren T., Wilkinson P., Prescott R.J., Quinn K.J., Tedeschi M

Feeling worse after a B12 injection is exceedingly rare

Biomarkers can be discovered in tissue or biofluids in nonclinical studies, but generally, the most useful biomarkers in the clinical setting are biomarkers detected in biofluids and are directly related to a mechanism of liver toxicity or a functional change in the liver

(Aureli A, et al., International Journal of Molecular Sciences, 2023 PubMed: 38068911 ) B12 and lipid metabolism A review of pre-clinical and clinical evidence found low B12 is associated with adverse lipid profiles including elevated total cholesterol and LDL, particularly in people with type 2 diabetes