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In the ITT population, after a median follow-up of 6.2 months, patients who received cabozantinib showed significant improvement in PFS compared with patients who received placebo (median not reached [96% CI, 5.7not estimable (NE)] vs

2 Materials and methods 2.1 Mouse strains C57BL/6 wild type (WT) obtained from the Federal University of Minas Gerais (UFMG) animal facility and several knockout (KO) mice were housed in a specific pathogen-free laboratory facility

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Subcutaneous dosing in research protocols is typically in the 1-2 mg range, though specific doses depend entirely on the study design and model

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