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Lesinurad and arhalofenate, inhibitors of URAT1 and OAT4, respectively, offer promising therapeutic avenues

Johnson VE, Stewart JE, Begbie FD, Trojanowski JQ, Smith DH, Stewart W

464,465 It also increases fatty acid uptake by moving CD36 to the membrane, inhibits ACC, reduces malonyl-CoA, and increases CPT1 activity

doi: 10.1038/nature14404 263 CannarileMAWeisserMJacobWJeggARiesCHRttingerD

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intakeR