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Multiple classes of advanced therapies, including both monoclonal antibodies and novel oral small molecules, are now available for the treatment of moderately-to-severely active Crohns disease and ulcerative colitis, highlighted by the approvals of the first IL23p19 antagonists, selective Janus kinase inhibitors and sphingosine-1-phosphate receptor modulators

Some, such as calix[n]arenes, have demonstrated the ability to inhibit azobisisobutyronitrile-induced linoleic acid peroxidation, while others, like porphyrins, are effective in suppressing peroxidation processes in vivo

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Long-term effects of cabergoline and levodopa in Japanese patients with early Parkinson's disease: a 5-year prospective study

Or, maybe the doses were too high

Disruption of prefrontal brain activation top-down control of working memory capacity as possible mechanism for chemo-fog/brain (chemotherapy-associated cognitive impairment)