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GCL belongs to the class of proteins that are sensitive to oxidative stress, and its expression is mainly under the regulation of the Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), a transcription factor that regulates a wide array of antioxidant responsive element-driven genes in various cell types (Baldelli et al., 2013)

It also poses dangers during pregnancy, where alcohol use can cause miscarriage, stillbirth, or fetal alcohol spectrum disorder, which affects the child's development

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Both CBS OPT and L2HGDH OPT are about 7KDa larger than the endogenous ones

Hernndez-Cerda J, Bertomeu-Gonzlez V, Zuazola P, Cordero A