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What exists is preclinical, and it is thin: Rodent and in-vitro work described procognitive and synaptogenic effects (McCoy 2013, PMID 23055539 now under an Expression of Concern

Head-to-head data from the SURMOUNT trials showed tirzepatide producing slightly greater weight loss at equivalent treatment durations

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The peptide normalizes nitric oxide and malondialdehyde levels while increasing expression of antioxidant enzymes heme oxygenase-1 and NOS-3[11]

However, to facilitate coordination of Medicare and Medicaid services, the Medicare Improvements for Patients and Providers Act (MIPPA) of 2008--as amended by the Patient Protection and Affordable Care Act--required all DSNPs to have contracts with the states in which they operate (CMS, 2016b)