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The rationale for developing AOD-9604 was based on research showing that the 176191 fragment of GH retained the lipid-metabolizing (lipolytic) properties of the full protein while lacking the ability to stimulate IGF-1 production or affect glucose/insulin metabolism

Elevated NNMT activity has been associated with increased fat accumulation, reduced metabolic efficiency, and impaired cellular energy production

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Furthermore, research published in the journal Obesity Science & Practice highlighted the benefits of semaglutide for long-term weight maintenance, demonstrating sustained reductions in body weight and improvements in obesity-related comorbidities over time