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doi: 10.2147/PPA.S110632

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Traditional surgical, genetic and pharmacological studies have tested systemic actions of circulating androgens, and more recent transgenic approaches have allowed for tests of AR gene function in specific androgen responsive niches contributing to body composition, including: skeletal muscle and surrounding interstitial cells, white and brown adipose, as well as trabecular and cortical bone

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In addition, damage caused by peroxynitrite (ONOO ) in AD patients is documented by the increased level of 3-nitrotyrosine (3-NT or 3-NO 2 Tyr) (Smith et al