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As has been discussed above, some organisms (especially pathogens) seem to be able to withstand high levels of amino acid misincoporation, or even be able to dispense of the editing function altogether, making the editing a less promising target

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Overload of mitochondria with ammonium instigates over-production of reactive oxygen species and opening of mitochondrial permeability transition pore, which further damages astrocytes and induce astrocyte swelling

Estrada-Snchez et al., 2009) associated with decreased EAAT2 function in synaptosomes (Livens et al., 2001) or acute cortico-striatal slices (Shin et al., 2005)