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My understanding is that this should be done routinely, especially if you're on B12 in high doses, but most GP's don't know this and don't do it
Freezing causes ice crystal formation, which physically disrupts the molecular structure of B12 and lipotropic compounds
2017 Jun;6(6):2222-2225 Kulshreshtha B, Pahuja I, Kothari D, Chawla I, Sharma N, Gupta S, Mittal A
These findings substantiate its standing as the gold standard preventative for porcine neonatal anemia
