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doi: 10.3945/jn.108.098269 8

6.4 Clinical positioning Based on the existing preclinical and early clinical evidence, the potential clinical application scenarios of the cuproptosisICD synergistic therapy mainly cover the following three dimensions: (I) Drug Resistance Reversal Strategy: For patients with epidermal growth factor receptortyrosine kinase inhibitor (EGFRTKI)-resistant LUAD or chemotherapy-resistant LUSC, the unique mechanism of the cuproptosis-independent apoptotic pathway is utilized to overcome classical therapeutic resistance caused by Bax/Bak deficiency or Caspase inactivation (Wang X